How to Support Multiple SMTP Domains in a Front-End and Back-End Topology
If you run Exchange 2003 in a front-end and back-end topology that includes multiple SMTP namespaces, you must create additional HTTP virtual servers in the Exchange Virtual Server for each domain namespace. For example, if contoso.com hosts Exchange Server 2003 for both tailspintoys.com and wingtiptoys.com, three virtual servers are necessary—the default virtual server, a virtual server for tailspintoys.com, and a virtual server for wingtiptoys.com. This configuration provides maximum flexibility in determining which resources are available to each hosted company.